Currently? SEX CRIMINALS if you’re a grown-up. I’m less sure about the best ongoing title for kids. Kate Leth might have some suggestions.
Older stuff? SANDMAN, THE LEAGUE OF EXTRAORDINARY GENTLEMEN vol. 1, Y: LAST MAN if you’re an adult. (SANDMAN has actually just returned for a limited run, and is dizzying in its awesomeness). For kids, I’d recommend BONE by Jeff Smith. For kids and adults both, the complete CALVIN & HOBBES is as important, probably, as HUCKLEBERRY FINN. No, seriously.
Agreed on all counts.